LYODRY FREEZE DRYERS

The LyoDry Compact benchtop freeze dryer is a cost-effective solution for laboratories in search of a reliable, affordable benchtop lyophilizer that is designed and manufactured in the UK. The LyoDry Compact offers condenser temperature options of either -55°C or -85°C, with an ice capacity of 5Kg per batch and is modular, allowing it to be used with a variety of freeze dryer chambers and accessories. LyoDry Compact was initially created to serve as a direct replacement for the obsolete Edwards Modulyo freeze dryer, featuring an accessory flange that is identical, allowing freeze drying chambers and accessories to be typically compatible with both models. The latest generation LyoDry Compact incorporates many modern day enhancements, including: a polished stainless steel chassis - ideal for laboratory environments a bright, clear LCD digital display which is visible even from a distance temperature units in Celsius or Fahrenheit; vacuum units in millibar, Torr or pascal a system start-up bar clearly indicating the time remaining until 'Ready' vacuum pump control on-screen with simple commands automatic hot gas defrost The LyoDry Compact offers a variety of freeze drying chambers and accessories for you to choose from. Options range from a clear acrylic chamber with lid and L-gaskets, stainless steel tray accessory (with or without heater mats and a controller), a column manifold for flask drying, an acrylic chamber with a ported lid for bulk and flask drying needs and a vial stoppering accessory. Additionally, we provide a bell jar for smaller batches, secondary drying manifolds and spin freezers, and a vial stoppering accessory. The recommended vacuum pump provided is an oil rotary vane vacuum pump by default, or a dry scroll vacuum pump can be supplied if an oil-free option is preferred. We can also offer guidance on whether your current vacuum pump is suitable. As its name suggests, the LyoDry Compact occupies a compact footprint. It is designed to sit on a laboratory bench; or for added height, convenience and portability, on an optional purpose-built, stainless steel trolley which has a lower shelf for the vacuum pump, with castors and brakes. If you are looking for an economical, versatile benchtop freeze dryer, consider the LyoDry Compact. You can either buy it directly or opt for a hire-to-buy plan for the -55°C version, allowing you to pay in monthly installments over 12 months (terms and conditions apply; the first 3-months payment is required in advance). Alternatively, reconditioned benchtop freeze dryers with an acrylic chamber, tray accessory and vacuum pump can be rented  from £650.00 per month. If additional features are required, such as data logging, real-time and historical temperature and pressure trends, touch screen, ethernet communications, and USB connectivity, the LyoDry Benchtop Pro provides a more closely controlled freeze-drying process. Assistance is readily available for any help you may need, whether it's selecting your freeze dryer or seeking advice after your purchase. On-site installation and training for operators, annual service contracts, and on-demand maintenance services are all offered in the UK if necessary. Our customer service is top-notch, and we consistently receive positive feedback. Read more about: LyoDry Compact benchtop freeze dryer LyoDry Benchtop Pro freeze dryer Freeze dryer chambers and accessories The complete range of LyoDry Freeze Dryers Please c ontact us for any further information and/or a quotation,

The LyoDry Compact benchtop freeze dryer - UK designed, manufactured and supported - is the optimum choice for laboratories seeking a quality assured, budget friendly, benchtop lyophilizer. LyoDry Compact has a 5Kg capacity ice condenser with temperature options of either -55°C  or -85 °C and can be used with a wide choice of drying chambers and freeze drying accessories. Originally designed to directly replace the (obsolete) Edwards Modulyo freeze dryer, the LyoDry Compact has an identical accessory flange so that drying accessories are directly interchangeable. Whilst also providing some end-user familiarity for Modulyo users, the latest LyoDry Compact includes many contemporary enhancements, including: a lab-friendly, polished stainless steel chassis automatic hot gas defrost a bright, clear LCD display which is visible even from a distance vacuum units in millibar, Torr or pascal & temperature units in Celsius or Fahrenheit a system start-up bar which clearly indicates time remaining until 'Ready' on-screen vacuum pump control with easy to follow commands Freeze drying chamber options include a clear acrylic chamber with lid and L-gaskets and stainless steel tray accessory (unheated or with heater mats and a controller), a bell jar for smaller batches, a column manifold for flask drying or, where bulk and flask drying are needed, an acrylic chamber with ported lid for flasks. Accessory options also include a secondary drying manifold and spin freezer. The recommended vacuum pump can also be quoted or we will be happy to advise whether your existing vacuum pump is suitable. LyoDry Compact occupies, as its name suggests, a compact footprint. It is designed to sit on a laboratory bench or, for added height convenience and portability, on an optional purpose-built, stainless steel trolley which has a lower shelf for the vacuum pump, castors and brakes. This is our most budget friendly model which can be purchased outright, or there is a hire-to-buy option for the -55°C version which enables buyers to purchase new equipment via monthly payments. Alternatively, used benchtop freeze dryers with an acrylic chamber, tray accessory and vacuum pump can be rented from £650.00 per month. Finally but importantly, support is always on hand whether you need guidance with choosing your freeze dryer or after sales advice. On-site set-up and operator training, an annual service contract or maintenance on-demand are available as required. Our customer service is first class and we receive excellent feedback . For any further information and/or a quotation, please contact us .

Choosing a freeze dryer chamber or spare parts for your LyoDry or Modulyo freeze dryer? MechaTech Systems offers chambers and spare parts which are suitable for use with both our LyoDry laboratory freeze dryers and most Edwards Modulyo and Supermodulyo freeze dryers. Explore our selection to find the ideal fit for your lab's freeze dryer. MechaTech's freeze dryer accessories and spare parts are: Designed for interchangeability: MechaTech's LyoDry laboratory freeze dryers (Benchtop and Midi) were created as direct replacements for Edwards Modulyo and Supermodulyo models. Compatible parts: As a result, MechaTech's freeze dryer accessories and spares typically work with Edwards freeze dryers as well. Verification assistance: If you have any doubts, MechaTech is happy to help you confirm compatibility. For Bulk Freeze Drying, our most popular Acrylic Chamber (LSDC) is a direct replacement for the Edwards acrylic chamber (part number F056-52-000). Key features include: Spacious Design: Being a large size (350mm diameter x 435mm high), it's ideal for bulk freeze drying applications. Complete Package: It comes ready to use with removable lid and L-gaskets. For smaller samples or a lower budget, the Acrylic Bell Jar (LSDCS) is another great option (measurements provided). Maximise sample throughput using our drying racks, which are compatible with LSDC acrylic chamber. Here are two options to consider: 6-Tray Drying Rack (LSD6): This features removable stainless steel trays (284mm diameter x 30mm high) offering a total drying area of 0.38m². Freeze-dry multiple samples simultaneously for maximum efficiency. 2-Tray Drying Rack (LSD2): This space-saving option features two flat stainless steel trays (each measuring 310mm with a 132.5mm space between layers). Want to freeze dry your samples faster? Speed up with the Heated Tray Drying Accessory (LSAD6H). This accessory combines the Acrylic Chamber with a 6-tray drying rack and integrates heat via heater mats and a temperature controller (0°C – 60°C) to accelerate the freeze-drying process. Need versatility? The Acrylic Chamber with 8-port lid (LSDCV) offers the flexibility to freeze dry both: Bulk Samples: Add the 6-tray drying rack accessory (LSD6) for efficient bulk drying. Samples in Flasks: Each of the 8 ports, equipped with a neoprene valve, accommodates flasks up to 1 liter capacity. With the Acrylic Chamber with 8-port lid, you can seamlessly switch between drying methods based on your sample requirements. Maximize Flask Freeze Drying with the 24-Port Column Manifold. If you need to freeze-dry large volumes of samples in flasks, but want to skip the trays, the 24-port column manifold (LSPM24) is the perfect solution. This stainless steel manifold offers: High Capacity: Equipped with 24 ports, each fitted with a 3/4" ID neoprene valve, you can freeze-dry multiple large flasks (up to 1 litre capacity) simultaneously. Space-Saving Design: The radial port arrangement maximizes efficiency by utilizing the space around the central column. Flask-Focused Functionality: Ideal for labs that primarily rely on flask-based freeze drying. With the 24-port column manifold, you can increase your freeze-drying throughput for large volume flask samples. We also supply the neoprene valves (part number LSRV) individually too, along with B19, B24 and B29 rubber adaptors (which connect the valve to the manifold). If you already have an Edwards column manifold or drum manifold and just need replacement valves, these are compatible too, directly replacing the old Edwards part number, F056-48-000. For freeze drying in ampoules, we supply Spin Freezers and Secondary Drying Manifolds , either with your new LyoDry Benchtop or Midi freeze dryer, or as replacements to suit your Edwards Modulyo or Supermodulyo freeze dryer. The Spin Freezer (LSSP) employs evaporative cooling and centrifugation to rapidly freeze samples in a thin layer on one side of each ampoule. To ensure compatibility with a wide range of ampoules, the Spin Freezer comes with five interchangeable carriers. The Secondary Drying Manifold (LSDM96) offers a choice of 96, 48, or 24 ports, all equipped with adaptor nipples for efficient desorption (secondary drying) of ampoule samples. We also supply spare adaptor nipples (part number LSAN) in packs of 48 units, for the secondary drying manifold (also compatible with the older Edwards secondary drying manifolds). Need high-capacity freeze drying on a lab-friendly budget?  The LyoDry Midi condenser paired with our spacious 10-tray stainless steel chamber (LSCC10) offers significant advantages: Cost-Effective Capacity: The LyoDry Midi condenser (replacing the Supermodulyo EF12K condenser) provides a budget-conscious alternative to expensive pilot scale models, providing larger capacity. Maximum Drying Area: The 10-tray chamber has a large1.5m² drying area, ideal for handling large sample volumes. Versatile Options: Choose between unheated or heated versions of the chamber to perfectly suit your specific drying requirements. Additionally, a manifold assembly can be incorporated for flask drying applications. Supermodulyo Compatibility: This chamber can even be retrofitted to your existing Supermodulyo freeze dryer condenser. With the LyoDry Midi condenser and 10-tray chamber, you can achieve higher capacity freeze drying without a pilot scale price tag. Further information: See our full range of Freeze Dryer Chambers, Accessories and Spares > See LyoDry Benchtop Freeze Dryers > See LyoDry Midi Freeze Dryers > If you have questions or would like a quotation please Contact Us >

MechaTech Systems supply freeze dryer chambers and spare parts which are suitable for use with our own range of LyoDry freeze dryers and Edwards Modulyo and Supermodulyo freeze dryers. Read on to compare and find the best fit for your laboratory freeze dryer. LyoDry laboratory freeze dryers (including Benchtop and Midi lyophilizers) were originally designed to directly replace Edwards Modulyo and Supermodulyo freeze dryers. So, our freeze dryer accessories and spares are usually compatible with Edwards freeze dryers too. If you're unsure, we will be pleased to check this for you. Our most popular drying chamber is the Acrylic Chamber (part number LSDC) The acrylic chamber directly replaces the Edwards acrylic chamber (part number F056-52-000) and is supplied complete with removable lid and 2 x L-gaskets. Measuring 350mm diameter x 435mm high, it is ideal for a wide range of bulk freeze drying applications. Alternatively, if you need a smaller, cheaper option, the Acrylic Bell Jar (part number LSDCS) measures 212mm diameter x 215mm working height and is supplied with the L-gasket. The Acrylic Chamber (LSDC) is commonly used with the 6-Tray Drying Rack (part number LSD6) with removable stainless steel trays, Each individual tray is 284mm diameter x 30mm high providing a total drying area of 0.38m ² , enabling freeze drying of multiple samples in a single cycle. Alternatively, we also supply a 2-Tray Drying Rack (part number LSD2) which has 2 x flat stainless steel trays each measuring 310mm, with a height of 132.5mm between each layer. Need to freeze dry faster? The Heated Tray Drying Accessory (part number LSAD6H) which includes the acrylic chamber and 6-tray accessory adds energy in the form of heat via heater mats and a temperature controller (0°C – 60°C). If you need the ability to freeze dry in flasks as well as bulk samples, the Acrylic Chamber with 8-port lid (part number LSDCV) can be used with either of the tray accessories mentioned above. Each of the 8 ports is fitted with a neoprene valve, 3/4" ID, suitable for flasks of up to 1 litre capacity. Or, if you are only freeze drying in flasks and need larger volume, the 24-port column manifold (part number LSPM24) in stainless steel is supplied complete with 24 neoprene valves mounted radially around the column, each of which are 3/4" ID, and suitable for flasks of up to 1 litre capacity. We also supply the neoprene valves (part number LSRV) individually too, along with B19, B24 and B29 rubber adaptors (which connect the valve to the manifold). If you already have an Edwards column manifold or drum manifold and just need replacement valves, these are compatible too, directly replacing the old Edwards part number, F056-48-000. For freeze drying in ampoules, we supply Spin Freezers and Secondary Drying Manifolds , either with your new LyoDry Benchtop or Midi freeze dryer, or as replacements to suit your Edwards Modulyo or Supermodulyo freeze dryer. The Spin Freezer (part number LSSP) employs evaporative cooling and centrifugation to freeze samples in a thin layer on one side of each ampule for faster drying, and it's supplied with 5 interchangeable carriers to accommodate ampoules of varying sizes and capacities. The Secondary Drying Manifold (part number LSDM96) is available with either 96, 48 or 24 ports (part number LSDM96) complete with adaptor nipples for desorption (secondary drying) of samples in ampoules. We also supply spare adaptor nipples (part number LSAN) in packs of 48 units, for the secondary drying manifold (also compatible with the older Edwards secondary drying manifolds). If greater capacity is required but on a laboratory scale budget (as opposed to more expensive pilot scale models), the LyoDry Midi freeze dryer condenser (which replaces the Supermodulyo EF12K condenser) can be used with our 10-tray, stainless steel chamber (part number LSCC10). This provides up to 1.5m ² drying area and is available either unheated or heated, and can also be fitted with a manifold assembly for additional flask drying. This chamber can also be retrofitted to a Supermodulyo freeze dryer. For any further information: See our full range of Freeze Dryer Chambers, Accessories and Spares > See LyoDry Benchtop Freeze Dryers > See LyoDry Midi Freeze Dryers > If you have questions or would like a quotation please Contact Us >

MechaTech Systems repair and service freeze dryers. We can service at your site, or we can arrange collection at a time to suit, and carry out the service in-house at our dedicated service facility near Bristol, UK. Our engineers are experienced in the service and repair of a wide range of freeze dryer makes and models, including LyoDry, Modulyo and Modulyo-D, Supermodulyo, Scanvac, LyoTrap, and Zirbus. This includes the accompanying vacuum pump if required, including vacuum pumps manufactured by Edwards, Welch, Leybold, Pfeiffer, Agilent and Savant. Wherever possible, genuine spares are used and we maintain stocks of many standard spare parts to enable a fast turnaround. Freeze Dryer maintenance can be carried out at scheduled times, with a customised Service Contract to suit your operational and budgetary needs (with preferential Service contract rates and priority). Or simply contact us for on-demand repair or maintenance and we will send you a budgetary quote, so that you have an idea of costs beforehand. Each service and repair includes a 6 month warranty on the work completed and a Service Report for your records. We are located close to the M4/M5 interchange near Bristol, so we can be with you in a jiffy! We are ISO9001, F-Gas and Achilles certified and audited . We receive excellent feedback . Please contact our sales team for more information and a budgetary quote, by emailing enquiries@mechatechsystems.co.uk or phone us on 01454 414723. Or find out more: Maintenance and Repairs

Freeze Dryers are used for preservation of a wide variety of product types, as diverse as pharmaceutical products, food and beverages, soil samples, flowers and archaeological artefacts. If you are intending to purchase a freeze dryer for the first time, you may find the following information useful: Trials Have you carried out freeze drying trials of your product? Trials will help to determine how your product reacts to the freeze-drying process. E.g., the length of time to freeze dry a batch, how much ice it generates – before investing in capital equipment. You can carry out trials either by using a company that provides contract freeze-drying, or by hiring equipment and carrying out your own trials. MechaTech Systems offer benchtop freeze dryers for monthly rental > Budget How much can you afford? Freeze Dryers are expensive – fact! Prices do vary according to quality and manufacturer, but a good quality, 5Kg (ice condenser capacity) -55°C benchtop freeze dryer, including chamber and vacuum pump, is likely to start at around £11,000. For pilot and production scale freeze dryers, prices vary from tens to hundreds of thousand pounds, usually determined by the condenser and chamber size, and temperature and control requirements. Temperature What Condenser Temperature do you need? A freeze dryer typically has a condenser temperature of -55°C which is suitable for many product types, but not all. Your product may have a lower freezing point (eutectic point), in which case you will need a lower condenser temperature. MechaTech Systems manufacture LyoDry Freeze Dryers > with condenser temperatures of either -55 °C or -85°C. What Chamber Temperature do you need? Many small lab freeze dryers, such as the LyoDry Compact Benchtop Freeze Dryer >, or LyoDry Benchtop Pro > are modular: this means that you can choose the drying chamber > – often an acrylic chamber, perhaps with a tray accessory – or a manifold or chamber with ports for flask drying. In this instance, pre-freezing in the chamber is not an option, so your product must be pre-frozen either in a suitable freezer, or snap frozen in liquid nitrogen. Heating your product, if appropriate, may speed up the freeze-drying process. For this purpose, the LSAD6H Heated Chamber from MechaTech Systems has a temperature controller and heater mats. Larger, pilot-scale freeze dryers, such as the LyoDry Heritage > or the LyoDry Grande > do offer integral, temperature-controlled chambers or shelves. You can both pre-freeze and heat the product. LyoDry pilot and production scale freeze dryers are typically available with chamber temperatures ranging from -60°C or -40°C, to +60°C. Capacity What Condenser Capacity do you need? This will be determined by how much ice will your product generates before the condenser needs to be defrosted, and what batch size you wish to process. This is particularly important if you have a very wet product, which will generate more ice. For example, the LyoDry Compact benchtop freeze dryer has an ice condenser capacity of 5Kg, before defrost is required. The LHS60 LyoDry Heritage has an ice condenser capacity of 60Kg before defrost is required. If you don’t know how much ice your product generates, trials > will help you to determine this. What Chamber capacity do you need? i.e. How much space do you need for the product you wish to freeze dry per batch. Smaller, R&D freeze dryers, such as the LyoDry Compact benchtop freeze dryer, are often modular, so you can choose which chamber/drying accessory you need. This might be an Acrylic Chamber, for bulk samples, often with a tray accessory, for freeze drying multiple samples. Or a manifold accessory, for attaching flasks. Or a combination of both so that you have different options available, for example the LSDCV 8-port lidded acrylic chamber. See Freeze Dryer Accessories > for LyoDry Freeze Dryer accessory options. Pilot scale and production freeze dryers usually have an integral chamber, with a set number of shelves offering a total chamber capacity. For example, the pilot-scale LyoDry Maxi Freeze Dryer > is available with either 3, 4 or 5 shelves, each measuring 360mm W x 480mm D, up to a total of 0.86m2 drying space. Solvents What solvents are involved in the process? Often, the only solvent present in the freeze-drying process is water. In which case, any chamber is suitable. However, some organic solvents can cause an acrylic chamber to corrode, especially if a high concentration of corrosive solvent is present. In this instance, a stainless steel chamber is a better option. You may also need to protect the vacuum pump with a chemical trap and sorbent. Control What level of control automation do you need? Entry level, laboratory freeze dryers will usually have a basic digital controller and display, showing temperature, vacuum level and readiness. The operator needs to follow certain steps, such as pressing the ‘Pump On’ button to switch on the vacuum pump, when the freeze dryer display indicates that it has reached the correct pre-cooled temperature. For more closely controlled laboratory freeze drying on a small scale, the LyoDry Benchtop Pro > and LyoDry Midi Pro > offer touch screen control, data logging, trends, pressure control, USB and ethernet comms. Pilot and production freeze dryers, such as the LyoDry Heritage, Maxi and Grande, have more comprehensive controllers, usually a touch screen PLC, with pre-programmable, freeze drying ‘recipes’. These provide product protection and require only minimal operator intervention. They often include process and product temperatures variables, and real-time systems status and fault indicators. They also have comprehensive alarm management systems, and the option of remote view via an external computer. If you’re freeze drying in vials, some pilot and production freeze dryers, such as the LyoDry Maxi and Grande, also offer automatic stoppering of vials. Space and Logistics Last, but not least, where will your freeze dryer be installed? A benchtop freeze dryer can sit on a lab bench, or a purpose-built trolley on castors so that it can be moved around the lab. For example, the LyoDry Midi modular freeze dryer offers a larger condenser capacity (18Kg) than a LyoDry benchtop freeze dryer (5Kg), but is specially designed be positioned next to a typical laboratory bench. The LyoDry Maxi has a built-in chamber on top, so needs height, but is specially designed to fit through a standard laboratory doorway. The LyoDry Production Freeze Dryer >, however, is a through-the-wall design – so only the chamber doorway and operator control are accessible in the clean room, whilst the mechanical parts such as the vacuum pump and condenser are in a separate room. To summarise: Have you carried out trials > ? What can you afford > ? What temperature > do you need? What capacity > do you need? What solvents> are you using? What level of control > do you need? How much space > do you have? MechaTech Systems manufacture LyoDry Freeze Dryers >, from our Bristol, UK facility. We can provide advice, quotations and also practical help in the form of rental benchtop freeze dryers for carrying out trials of your product. For further information, please contact us: enquiries@mechatechsystems.co.uk / +44 (0) 1454 414723

Benchtop freeze dryers are often used for small scale freeze drying or research and development projects. The choice is sometimes driven more by budget than capacity requirements. What if you need a freeze dryer that is bigger than a benchtop but without the pilot scale price tag? Benchtop freeze dryers are not usually chosen for their capaciousness. LyoDry Benchtop freeze dryers have a 5Kg ice condenser capacity. This means that they will process up to a maximum of 5Kg of the ice that is created from the product moisture, per batch. They are often used with an acrylic chamber and tray accessory for bulk freeze drying. But if you really need a larger freeze dryer, without paying automated pilot scale freeze dryer prices, the LyoDry range of freeze dryers includes more attainable, low cost pilot scale freeze drying, in the form of the LyoDry Midi and LyoDry Midi Pro. The LyoDry Midi freeze dryer condenser is free standing and designed to fit beside a standard laboratory bench (the footprint is analogous to a washing machine, rather than a microwave). The LyoDry Midi has an 18Kg ice condenser capacity, which is useful if you're freeze drying a very moist product and want to freeze dry in larger batches between defrost. The vacuum pump (an Edwards RV12 as standard or an Edwards nXDS15i dry scroll pump if preferred) is integral and easily accessible for maintenance. Like the benchtop freeze dryer, the LyoDry Midi is modular: this means that you can choose your drying chamber and accessory. Thus it can be used with the standard acrylic chamber and tray accessory, just like the benchtop freeze dryer. But if you're really looking to scale up your drying capacity, then the LSCC10 10-tray drying chamber is designed for use with the LyoDry Midi and offers ample volume. LSCC10 has 10 trays, each individual tray measuring 450 mm x 345 mm x 30 mm, giving a total drying area of 1.5m². Available unheated as standard, one option is heating to 60°C. Another option is a manifold valve attachment for flask drying fitted to the side of the chamber. If the LyoDry Midi with LSCC10 chamber sounds appealing but you also need data logging, analysis,pressure control, USB and ethernet connections, then the LyoDry Midi Pro includes this added functionality. Other advantages of the LyoDry Midi Pro include colour touch screen control and, if used with a heated chamber, pre-programmable freeze drying recipes can be used, simplifying the whole process even further. To summarise, LyoDry Midi and LyoDry Midi Pro are lab scale freeze dryers with the potential for pilot scale freeze drying more economically. Read more about the LyoDry Midi Read more about the LyoDry Midi Pro Contact Us for a quotation or any further information

Benchtop freeze dryers are often used for small scale freeze drying or research and development projects. The choice is sometimes driven more by budget than capacity requirements. What if you need a freeze dryer that is bigger than a benchtop but without the pilot scale price tag? Benchtop freeze dryers are not usually chosen for their capaciousness. LyoDry Benchtop freeze dryers have a 5Kg ice condenser capacity. This means that they will process up to a maximum of 5Kg of the ice that is created from the product moisture, per batch. They are often used with an acrylic chamber and tray accessory for bulk freeze drying. But if you really need a larger freeze dryer, without paying automated pilot scale freeze dryer prices, the LyoDry range of freeze dryers includes more attainable options, such as the LyoDry Midi and LyoDry Midi Pro. The LyoDry Midi freeze dryer condenser is free standing and designed to fit beside a standard laboratory bench (the footprint is analogous to a washing machine, rather than a microwave). The LyoDry Midi has an 18Kg ice condenser capacity, which is useful if you're freeze drying a very wet product and want to freeze dry in larger batches between defrost. The vacuum pump (an Edwards RV12 as standard or an Edwards nXDS15i dry scroll pump if preferred) is integral and easily accessible for maintenance. Like the benchtop freeze dryer, the LyoDry Midi is modular: this means that you can choose your drying chamber and accessory . Thus it can be used with the standard acrylic chamber and tray accessory, just like the benchtop freeze dryer. But if you're really looking to scale up your drying capacity, then the LSCC10 10-tray drying chamber is designed for use with the LyoDry Midi and offers ample volume. LSCC10 has 10 trays, each individual tray measuring 450 mm x 345 mm x 30 mm, giving a total drying area of 1.5m ². Available unheated as standard, one option is heating to 60°C. Another option is a manifold valve attachment for flask drying fitted to the side of the chamber. If the LyoDry Midi with LSCC10 chamber sounds appealing but you also need data logging, analysis,pressure control, USB and ethernet connections, then the LyoDry Midi Pro includes this added functionality. Other advantages of the LyoDry Midi Pro include colour touch screen control and, if used with a heated chamber, pre-programmable freeze drying recipes can be used, simplifying the whole process even further. LyoDry Midi and LyoDry Midi Pro are lab scale freeze dryers with the potential for pilot scale freeze drying more economically. Read more about the LyoDry Midi Read more about the LyoDry Midi Pro Contact Us for a quotation or any further information

As LyoDry Freeze Dryers manufacturers, we also supply a comprehensive range of freeze dryer accessories, such as chambers, trays, spin freezers and secondary drying manifolds, to name but a few. Which chamber is best for your benchtop freeze drying application? The freeze dryer chamber and accessories that we supply for both benchtop (5Kg condenser) and Midi (18Kg condenser) are compatible not only with LyoDry freeze dryers, but also with most Edwards and Savant EF4K Modulyo and EF12K Supermodulyo freeze dryers. The Acrylic Chamber (part no LSDC) and 6-Tray Drying Rack (part no LSD6) with stainless steel trays enables freeze drying of multiple samples in a single cycle. LSDC directly replaces the obsolete Edwards chamber (part number F056-52-000). LSD6 tray drying rack has 6 removable trays, each of which measure 284mm diameter, providing a total drying area of 0.38m². This is our most popular freeze dryer chamber configuration for benchtop lyophilizers. Need to freeze dry faster? Adding heat to a simple benchtop freeze dryer chamber can speed up the freeze drying process. The Heated Tray Drying Accessory (part number LSAD6H) incorporates the acrylic chamber, tray accessory, with the addition of heater mats and a temperature controller (0°C – 60°C). If you need more flexibility, to freeze dry in flasks and bulk samples, the Acrylic Chamber with 8-port lid (part no LSDCV) can be used with the 6-tray accessory mentioned above. Each of the 8 ports is fitted with a neoprene valve, 3/4" ID, suitable for flasks of up to 1 litre capacity. For freeze drying only in flasks, the 24-port column manifold in stainless steel is supplied complete with 24 neoprene valves, each of which are 3/4" ID, and suitable for flasks of up to 1 litre capacity. We also supply the neoprene valves (part number LSRV) as spares, along with B19, B24 and B29 rubber adaptors, which connect the valve to the manifold. If you already have an Edwards column manifold or drum manifold and just need replacement valves, these are compatible too, directly replacing the old Edwards part number, F056-48-000. For freeze drying in ampoules, we supply the Spin Freeze: a self-contained vacuum chamber designed to facilitate freezing and primary drying of samples in ampoules. The Spin Freeze (part no LSSP) employs evaporative cooling and centrifugation to freeze samples in a thin layer on one side of each ampule for faster drying, and it's supplied with 5 interchangeable carriers to accommodate ampoules of varying sizes and capacities. We also supply Secondary Drying Manifolds - designed to accommodate secondary drying of samples contained in ampoules. The Secondary Drying Manifold is available with either 24, 48 or 96 ports (part number LSDM96) for desorption (secondary drying) of samples in ampoules. Spare adaptor nipples (part number LSAN) are also available in packs of 48 units, for the secondary drying manifold (also compatible with the older Edwards secondary drying manifolds). If greater capacity is required but on a laboratory scale budget (as opposed to pilot scale models), the LyoDry Midi freeze dryer condenser (which replaces the Supermodulyo EF12K condenser) can be used with our 10-tray, stainless steel chamber (part no LSCC10). This provides up to 1.5m² drying area and is available either unheated or heated, and can also be fitted with a manifold assembly for additional flask drying. This chamber can also be retrofitted to a Supermodulyo. Any questions? Or if you would like a quotation, please Contact Us More information online: See our full range of Freeze Dryer Chambers, Accessories and Spares See LyoDry Benchtop and Midi Freeze Dryers

LyoDry Benchtop Freeze Dryers are designed, manufactured and supported from our site near Bristol, UK. We receive excellent feedback. Used and endorsed by universities, government research institutes, blue chip pharmaceutical manufacturers, chefs and restaurants - in the UK and overseas - LyoDry Benchtop Freeze Dryers have options to suit both your budget and technical requirements. LyoDry Benchtop Freeze Dryers were originally designed to directly replace the (now obsolete) Modulyo range of freeze dryers, which were manufactured by Edwards and subsequently Thermo Savant. Consequently, LyoDry Benchtop Freeze Dryers are compatible with most drying chambers and accessories previously used with the Modulyo. So, if you only wish to upgrade either your Modulyo condenser, or your Modulyo drying chamber / accessory, then you can do so with either a LyoDry Freeze Dryer Condenser, or a LyoDry Drying Chamber / Accessory. All LyoDry Benchtop Freeze Dryers have the benefit of a fully stainless steel cabinet, making them ideal for freeze drying in lab, pharma and food environments. They also have hot gas defrost for a faster turnaround between batches. We also supply the recommended vacuum pump if required - either a rotary vane oil pump or an oil-free dry pump if preferred - or will be pleased to advise whether your existing vacuum pump is suitable. A purpose built, stainless steel trolley is available if required, fitted with castors and brakes and a lower shelf to accommodate the vacuum pump. This is sometimes more convenient, being lower than a laboratory bench and adding portability. There are two models of LyoDry Benchtop Freeze Dryers available: - The LyoDry Compact is our entry level benchtop freeze dryer. It has an ice condenser temperature of -55°C (part number LSBC55) or -85°C (part number LSBC85), with an ice capacity of 5Kg per batch. LyoDry Compact is a modular freeze dryer, therefore you can choose from a range of drying chambers, tray accessories and manifold options to suit bulk or flask drying. A clear, LCD display facilitates on-screen control of the vacuum pump and user changeable vacuum and temperature units. The LyoDry Benchtop Pro is designed for more closely controlled freeze drying, with the added features of data logging, real time and historical temperature and pressure trends, ethernet comms, pressure control and a wide, touchscreen, colour operator interface with icons for easy navigation. If the LyoDry Benchtop Pro is used with our Heated Tray Accessory (part number LSAD6H), then multiple profile creation ('freeze drying recipes') is an added benefit. LyoDry Benchtop Pro is also available with a condenser temperature of either -55°C (part number LSB55P) or -85°C (part number LSB85P), and an ice capacity of 5Kg per batch. Ancillary services include the options of delivery to your site by courier, or delivery by one of our engineers, with on-site set up and basic operator training. We offer on-demand servicing or prescheduled annual service contracts with preferential rates. Service contracts can be tailored to suit, and can include other freeze drying/vacuum equipment that you may have on-site, if required. Spare parts and accessories are readily available, often from stock. LyoDry Freeze Dryers conform to the latest environmental standards, manufactured by F-Gas certified engineers using CFC free refrigeration gas. LyoDry Freeze Dryers are designed to have fast cool down times, helping to minimise energy consumption and maximise life expectancy. They are high end, competitively priced and quality assured. We receive excellent feedback. Read more about LyoDry Compact Benchtop Freeze Dryers Read more about LyoDry Benchtop Pro Freeze Dryers Read more about LyoDry Chambers and Accessories Contact us for a quotation or more information

As LyoDry Freeze Dryers manufacturers, MechaTech Systems also supply a large range of freeze dryer accessories - chambers, trays, spin freezers etc - and spare parts which are suitable for use with LyoDry Laboratory freeze dryers. Wondering which is best for your freeze drying application? Read on...! LyoDry 'Laboratory Freeze Dryers' includes our Benchtop range and also our Midi range . LyoDry laboratory freeze dryers were designed to directly replace the (now obsolete) Edwards Modulyo and Supermodulyo range. Therefore, our freeze dryer accessories and spares are usually compatible with these freeze dryers too (if you're unsure, we will be pleased to check this for you). Our most popular drying chamber accessory is the Acrylic Chamber and 6-Tray Drying Rack with removable trays, which enables freeze drying of multiple samples in a single cycle. The acrylic chamber directly replaces the obsolete Edwards chamber (part number F056-52-000). Need to add heat? Our Heated Tray Drying Accessory includes the acrylic chamber, tray accessory, h eater mats and temperature controller (0°C – 60°C). If you need more flexibility, with the ability to freeze dry in flasks as well as bulk samples, the Acrylic Chamber with 8-port lid can be coupled with the tray accessory mentioned above. Each of the 8 ports is fitted with a neoprene valve, 3/4" ID, suitable for flasks of up to 1 litre capacity. We also offer this chamber with a stainless steel chamber if preferred. Or if you are only freeze drying in flasks, the 24-port column manifold in stainless steel is compatible both with LyoDry Benchtop and Midi freeze dryers and also Modulyo and Supermodulyo models. It is supplied complete with 24 neoprene valves, each of which are 3/4" ID, and suitable for flasks of up to 1 litre capacity We also supply the neoprene valves individually too, along with B19, B24 and B29 rubber adaptors (which connect the valve to the manifold). If you already have an Edwards column manifold or drum manifold and just need replacement valves, these are compatible too, directly replacing the old Edwards part number, F056-48-000. For freeze drying in ampoules, we supply Spin Freezers and Secondary Drying Manifolds , either with your new LyoDry Benchtop or Midi freeze dryer, or as replacements to suit your Edwards Modulyo or Supermodulyo. The Spin Freezer employs evaporative cooling and centrifugation to freeze samples in a thin layer on one side of each ampule for faster drying, and it's supplied with 5 interchangeable carriers to accommodate ampoules of varying sizes and capacities. The Secondary Drying Manifold is available with either 24, 48 or 96 ports (part number LSDM96) for desorption (secondary drying) of samples in ampoules. We also supply spare adaptor nipples (part number LSAN) in packs of 48 units, for the secondary drying manifold (also compatible with the older Edwards secondary drying manifolds). If greater capacity is required but on a laboratory scale budget (rather than the more expensive pilot scale models), the LyoDry Midi freeze dryer condenser (which replaces the Supermodulyo EF12K condenser) can be used with our 10-tray, stainless steel chamber. This provides up to 1.5m ² drying area and is available either unheated or heated, and can also be fitted with a manifold assembly for additional flask drying. This chamber can also be retrofitted to a Supermodulyo. See our full range of Freeze Dryer Chambers, Accessories and Spares > See LyoDry Benchtop Freeze Dryers > See LyoDry Midi Freeze Dryers > For any further information or a quotation, please Contact Us >

If you are thinking about purchasing a freeze dryer, either for the first time or as an upgrade to your existing freeze dryer, you may find it helpful to consider the following points. Why freeze dry? Freeze Dryers are used for preserving a wide variety of product types, as diverse as pharmaceutical preparations, foods and beverages, soil samples, flowers and archaeological artefacts. The common objective is the long term preservation of a product without affecting its integrity. Freeze drying (also known as lyophilization) is a form of dehydration. By freezing the product and lowering the pressure, the moisture content of the product is removed. The freeze drying process facilitates preservation of the original shape, colour and properties of the product. Step 1: Freeze drying trials Have you carried out freeze drying trials of your product? Trials will help to determine how your specific product reacts to the freeze-drying process. For example, how long it takes to freeze dry a batch, how much ice your product generates and, importantly, how much it costs in terms of capital equipment and running costs. Trials can be accomplished either by using a company that offers contract freeze-drying, or by hiring equipment and carrying out your own trials. MechaTech Systems offer benchtop freeze dryers for monthly rental. Budget What can you afford? Freeze Dryers are expensive – fact! Prices vary according to equipment quality and manufacturer, but a good quality, 5Kg (ice condenser capacity). -55°C benchtop freeze dryer in the UK, including chamber and vacuum pump is likely to have a starting price over £10,000. For pilot and production scale freeze dryers, prices vary from tens to hundreds of thousand pounds, usually determined by the condenser and chamber size, and temperature and control requirements. Temperature What Condenser Temperature do you need? A freeze dryer typically has a condenser temperature of -50°C as a starting point. This is suitable for many product types, but not all. It depends upon the freezing (eutectic) point of your product. For example, if your product has a freezing point of -20°C, then a -50°C condenser temperature is fine, but if your product has a freezing point of -70°C, then you would need a condenser temperature of -85°C. MechaTech Systems offer freeze dryers with condenser temperatures of either -55 °C or -85°C. What Chamber Temperature do you need? Many small lab freeze dryers, such as Benchtop Freeze Dryers and the larger Midi Freeze Dryers , are modular: this means that you can choose the drying chamber – often an acrylic chamber, perhaps with a tray accessory – or a manifold or chamber with ports for flask drying. In this instance, pre-freezing in the chamber is not an option, so your product must be pre-frozen either in an external freezer, or snap frozen in liquid nitrogen. Heating your product, if appropriate, may speed up the freeze-drying process. For this purpose, the LSAD6H Heated Chamber from MechaTech Systems has a temperature controller and heater mats. Larger, pilot and production scale freeze dryers, such as the LyoDry Maxi , LyoDry Heritage or the LyoDry Grande include integral, temperature-controlled chambers or shelves. You can both pre-freeze and heat the product. MechaTech’s chamber freeze dryers are typically available with chamber temperatures ranging from -60°C or -40°C,  to +60°C. Capacity What Condenser Capacity do you need? A given condenser capacity refers to the ice capacity of the freeze dryer condenser per batch, before defrost is required. This is determined by how much moisture is in your original product, which converts to ice during the freeze drying process. This is particularly important if you have a very wet product, which is likely to generate more ice. For example, the LyoDry Compact benchtop freeze dryer has an ice condenser capacity of 5Kg, before defrost is required. The LHS60 LyoDry Heritage has an ice condenser capacity of 60Kg before defrost is required. If you don’t know how much ice your product will generate, trials will help you to determine this. What Chamber capacity do you need? i.e. How much space do you need for the product you wish to freeze dry per batch. Smaller, R&D freeze dryers, such as the LyoDry Compact , are often modular, so you can choose which chamber/drying accessory you need. This might be an Acrylic Chamber, for bulk samples, often with a tray accessory, for freeze drying multiple samples. Or a manifold accessory, for attaching flasks. Or a combination of both so that you have different options available, for example the LSDCV 8-port lidded acrylic chamber. See Freeze Dryer Accessories for LyoDry Freeze Dryer accessory options. Pilot scale and production freeze dryers usually have an integral chamber, with a set number of shelves offering a total chamber capacity. For example, the pilot-scale LyoDry Maxi Freeze Dryer is available with either 3, 4 or 5 shelves, each measuring 360mm W x 480mm D, up to a total of 0.86m2 drying space. Whereas the LSH60 LyoDry Heritage has a chamber housing 5 trays, providing a total of 5.2m² drying space. Solvents What solvents are involved in the process? Usually, the only solvent present in the freeze-drying process is water. In which case, any  chamber is suitable. However, some organic solvents can cause an acrylic chamber to corrode, especially if a high concentration of corrosive solvent is present,. In this instance, a stainless steel chamber is a better option. You may also need to protect the vacuum pump with a chemical trap and sorbent. Control What level of control automation do you need? Entry level, laboratory freeze dryers will usually have a basic digital controller and display, showing temperature, vacuum level and readiness. The operator needs to follow certain steps, such as pressing the ‘Pump On’ button to switch on the vacuum pump, when the freeze dryer display indicates that it has reached the correct pre-cooled temperature. For more closely controlled laboratory freeze drying on a small scale, the LyoDry Benchtop Pro and LyoDry Midi Pro offer touch screen control, data logging, trends, pressure control, USB and ethernet comms. Pilot and production freeze dryers, such as the LyoDry Heritage , Maxi and Grande , have more comprehensive controllers, usually a touch screen PLC, with pre-programmable, freeze drying ‘recipes’ and endpoint determination. These provide product protection and require only minimal operator intervention. They often include process and product temperatures variables, and real-time systems status and fault indicators. They also have comprehensive alarm management systems, and the option of remote view via an external computer. If you’re freeze drying in vials, some pilot and production freeze dryers, such as the LyoDry Maxi and Grande , also offer automatic stoppering of vials. Space and Logistics Last, but not least, where will your freeze dryer be installed? A benchtop freeze dryer can sit on a lab bench, or a purpose-built trolley on castors so that it can be moved around the lab. MechaTech Systems also manufacture the LyoDry Midi modular freeze dryer, which offers a larger condenser capacity (18Kg) than the benchtop freeze dryer (5Kg), but is specially designed be positioned next to a typical laboratory bench. The LyoDry Maxi has a built-in chamber on top, so needs height, but is specially designed to fit through a standard laboratory doorway.  The LyoDry Production Freeze Dryer , however, is a through-the-wall design – so only the chamber doorway and operator control are accessible in the clean room, whilst the mechanical parts such as the vacuum pump and condenser are in a separate room. To summarise: Have you carried out trials? What can you afford? What condenser temperature and chamber temperature do you need? What condenser capacity and chamber capacity do you need? What solvents are you using and what is their level of concentration? What level of control do you need? How much space do you have? MechaTech Systems manufacture LyoDry Freeze Dryers , from our Bristol, UK facility. We provide advice, quotations and also practical help in the form of rental benchtop freeze dryers for carrying out trials of your product. For further information, please contact us:  enquiries@mechatechsystems.co.uk / +44 (0) 1454 414723 or visit https://www.mechatechsystems.co.uk/freeze-dryers .